Oh!

Can't do that or you invite Bort's wrath!!!

To explain;
So let's say you have a 1st quarter Output made for 1st and 10.
Inside the output is 4 Inputs.
Inside those 4 Inputs are ONE Package in each one; each Package with 4 possible plays inside from which to choose from.
#1, The %'s from the Inputs must add up to 100%... COMBINED... not each. Otherwise the Bort machine takes total control and that can lead to some really bad juju. So, using what I posted just above, your Output has 4 Inputs so you can go 25% in each (which equals 100% total) or two Inputs with 30% and two with 20%... or 40-30-20-10%... anything that adds up to 100. For sake of argument, let's say you only have 3 Inputs in that Output. In that case, if you wanted EQUAL possibility for each Input to happen, you would give each Input a 33% chance. Yes... that only adds up to 99 but it doesn't go PAST 100 so the AI will function as you want it to... and not as Bort 'lord-knows-what'.
#2, Same principal for plays inside those Packages. The % should not exceed 100 COMBINED. So 4 plays at 25% each or 2 at 30% and 2 at 20%... ect, ect, ect.
Anytime you have more than a total % chance of over 100 then things can go sideways.
As for setting, again, if your chance (% settings) are equal across the line (in both the Packages and in the Inputs)... and they add up to 100% total... then since they're balanced %-wise you should go with Very Quickly or Quickly. If, however, your % settings differ (either from possibility of play inside the package or possibility of a specific Input happening) then I would leave it in the middle and let the % settings do their thing.
I think I can give you a decent example of when and how to use and not to use Adjust Very Quickly.
So, let's say I have a Output for 4th down and 1 yard or less to go.
Inside that Output I have 2 Inputs.
Inside one Input I have a Goal Line Run package.
Inside that package I have 4 Goal Line plays selected; HB Blast, FB Dive, QB Rollout Weak, and HB Sweep Strong.
I want the HB dive to be the most called play so I assign that a 40% setting. FB Dive gets a 10% chance. QB Rollout Weak and HB Sweep Strong get 25% chance each. This adds up to 10% so my Package is good to go. But, because the %'s vary I don't want Bort messing that up so I go with the middle 'Auto Adjust' setting. (FWIW, I never go with anything below that... have never seen the need to.)
Inside the other Goal Line Package I have 2 plays selected; FB Screen Weak and HB Screen Strong.
The Fb Screen gets a 50% chance and so does the HB screen. So here I would go with Auto Adjust = Very Quickly because I WANT Borts' AI to recognize if one play is working much better than the other... since both plays have an equal chance of happening. If it works as intended then the Bort machine will select the play that works better.
Now... concerning the 2 Inputs... I might do as follows;
Input #1, with the Goal Line Run Package selected, would be the one I want to have happen most often so I give it a 75% chance setting. The other Input has the Goal Line Pass Package so it would get a 25% chance setting. That adds up to 100% so everything is now set for that Output.