It's tough to stop the run and the pass in a collective effort! Best you can do is hope to limit your opponent to 3 ypc - I consider that a great day. One of the best ways is to keep their offense off the field and play situational run defense and really get to know the run playbook, ie spend a hell of a lot of time watching film and making changes.
Right now with the new AI the offense is ahead of the defense right now. But I think it's a matter of time before all the defensive wizards in GLB figure out the different schemes and builds to slow down the offense.