This also depends. I normally have my 1st target set to one of my fast receivers. Also if you have one stud WR you might want to set your target to him. I use check down as a last resort since my WRs are there to spread out the field. I do it sort of like the early 90 Cowboys did with a solid running attack but I still have the speed in my WRs and the strength in my QBs to hit them deep in a route this keeps teams from stacking the box against me. And results in me having some guys with a decent amount of yards.